Game Plans
Game plans reflect what you practice and prepare for a game. Some give a variety of small bonuses in different situations or when players perform specific tasks. Some affect ball distribution and some affect how the game is called.
Each coach will have his own preferences on this, so if you are letting coaches call your games (or playing in a league with custom playbooks/gameplans disabled) be sure to consider this when hiring a coach. A coach's preferences here also affects the kind of plays he will have in his playbook.
Offense
Attitude
Affects playcalling, a little more likely to go for it on 4th down and onside kicks. Also affects penalties.
Focus
Affects success rate of selection AND the inverse.
Tempo
Affects clock consumption.
Passing Preference
Affects success rate for selected range, with minor penalties to the others.
Passing Target
Affects targeting of players and minor bonus to passing.
Primary Receiver
Affects targeting on passes.
Third Down Back
Attempts to insert specified player on third downs.
Running Focus
Minor bonus to run type.
Running Back Role
Small increase in performance for selected role.
Backfield by Committee
Affect distribution of snaps.
Tight End Role
Small increase in performance for selected role.
QB Tuck and Run
Affects likelihood of QB running on failed pass play.
Defense
Attitude
Affects tackling, fumbles, missed tackles, interceptions, penalties.
Focus
Minor bonuses/penalties versus play type.
Primary Coverage
Affects performance of players coverage.
Defensive Line Role
Small increase in performance for selected role.
Linebacker Role
Small increase in performance for selected role.
Wear Player Radio
Give player radio to defender you think best supports both run and pass scenarios and has a decently high intelligence to be able to make improved decisions and inform teammates. Basically helps with recognition of plays to defend passes better, make better tackles, etc.
Match CBs to WRs
Affects play selection, will attempt to have at least as many CB on the field as there are WR. (i.e. selecting 335, nickel and dime plays when offense lines up in shotgun and spread.)
Align Man Coverage
Affects where defenders line up to cover receivers.
Target Player
Allows you to set a defensive focus for extra focus on an offensive player.
End Game Override
Winning
Allows additional focus when winning in late game
Losing
Allows additional focus when losing in late game